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This is due primarily to the substantial indirect costs related to reduced work productivity from HT-associated depression and anxiety—conditions for which patients with HT have markedly elevated odds ratios (3.56 and 2.32, respectively) ( 5 Supplements The literature on the clinical management of HT devotes considerable attention to the role of nutritional supplements, particularly selenium and vitamin D, in modulating the autoimmune process and alleviating persistent symptoms (59–61)

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