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Pro-NAC Trial: Combination Therapy with N-Acetylcysteine and Probenecid After Severe Traumatic Brain Injury in Children Given independent neurotherapeutic effects of probenecid [6] and NAC [3], potential synergism of combination therapy [50], favorable safety profiles and FDA approval of both drugs, and the fact that no targeted neurotherapeutics currently exist for treatment of TBI in humans, we embarked on a proof-of-concept, double-blind, placebo-controlled Phase I study of the combination use of probenecid and NAC in children with severe TBI (Pro-NAC Trial