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In addition to causing a drop in free CCL2 levels and a reduction in the level of tumor-infiltrating macrophages, this therapy resulted in a temporary antitumor activity (108)
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The 54 genes whose expression was reversed by GHK included “node molecules” YWHAB, MAP3K5, LMNA, APP, GNAQ, F3, NFATC2, and TGM2, all of which are involved in regulation of multiple biological functions through a complex molecular network [20]
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