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This IP3 promotes intracellular cytoplasmic Ca2+ influx, inducing the formation of calcium-calmodulin complex, which in turn activates myosin light chain kinase (MLCK), and consequent phosphorylation of myosin light chain (MLC), leading to contraction of airway smooth muscle, as shown in Figure 11
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Lastly, these treatments, when individually utilized, have generally shown a favorable safety profile
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