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NOT a peptide and NOT a drug — it is an endogenous molecule present in every cell Component 2 — biochemical role Hydrogen carrier in redox reactions and substrate for signalling enzymes — sirtuins, PARPs and CD38 (Rajman et al., 2018) Component 2 — biosynthesis Produced by the salvage pathway from the precursor nicotinamide, and de novo from tryptophan — the de novo route operating selectively in the liver in laboratory animals (Liu et al., 2018) Shared basis of the two components Both concern the same metabolic pathway: NNMT consumes nicotinamide, which is the precursor of NAD+ Study of the combination None